Spermidine/spermine N 1 -acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N 1 ,N 12 -bis(ethyl)spermine and to cisplatin
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Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.
The limited induction of spermidine/spermine N1-acetyltransferase (SSAT) activity has been implicated as an important determinant of the reduced response to the spermine analogue N1,N12-bis(ethyl)spermine (BESpm) by the cisplatin or cis-diamminedichloroplatinum(II) (cDDP)-resistant human ovarian carcinoma cell line (C13*). We checked whether or not under conditions of SSAT overexpression, enzym...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2005
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/bgi129